MovDisordV3, Main, Exploration, bibRecord, 006626

Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea

Identifieur interne : 006626 ( Main/Exploration ); précédent : 006625; suivant : 006627

Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea

Auteurs : A. M. Bonnet [France] ; Tell ; P. J. Schechter ; J. Grove ; M. H. Saint-Hilaire [France] ; Y. De Smet [France] ; Yves Agid [France]

Source :

Movement Disorders [ 0885-3185 ] ; 1987.

RBID : ISTEX:66F2876D6D1991ED6C2B9FA029DBAD69E93542BB

Descripteurs français

Pascal (Inist)
- Aminoacide, Biochimie, Chorée Huntington, GABA, Homme, Homocarnosine, Hérédodégénération, Hérédodégénération spinocérébelleuse Friedreich, Liquide céphalorachidien, Maladie dégénérative, Parkinson maladie, Système nerveux pathologie.
Wicri :
- topic : Biochimie, Homme.

English descriptors

KwdEn :
- Adult, Aged, Aminoacid, Biochemistry, Carnosine (analogs & derivatives), Carnosine (cerebrospinal fluid), Cerebrospinal fluid, Degenerative disease, Dipeptides (cerebrospinal fluid), Female, Friedreich Ataxia (cerebrospinal fluid), Friedreich ataxia, Friedreich's ataxia, GABA, Heredodegeneration, Homocarnosine, Human, Humans, Huntington Disease (cerebrospinal fluid), Huntington disease, Huntington's chorea, Levodopa (pharmacology), Male, Middle Aged, Nervous system diseases, Parkinson Disease (cerebrospinal fluid), Parkinson disease, Parkinson's disease, gamma-Aminobutyric Acid (cerebrospinal fluid).
MESH :
- chemical , analogs & derivatives : Carnosine.
- chemical , cerebrospinal fluid : Carnosine, Dipeptides, gamma-Aminobutyric Acid.
- cerebrospinal fluid : Friedreich Ataxia, Huntington Disease, Parkinson Disease.
- chemical , pharmacology : Levodopa.
- Adult, Aged, Female, Humans, Male, Middle Aged.

Abstract

Free and total γ‐aminobutyric acid (GABA) and homocarnosine concentrations were measured in the lumbar cerebrospinal fluid (CSF) of patients with Friedreich's ataxia, Huntington's chorea, and Parkinson's disease (with and without levodopa treatment), and compared with those determined in control subjects. Values found in Friedreich's ataxia or Parkinson's disease were not significantly different from those in controls. Unexpectedly, in Huntington patients, known to have a characteristic decrease in GABA and homocarinosine were significantly higher, whereas free GABA was not different from controls. These findings indicate that the measurement of CSF GABA and homocarnosine in patients with CNS degenerative diseases should be interpreted cautiously.

Url:

https://api.istex.fr/document/66F2876D6D1991ED6C2B9FA029DBAD69E93542BB/fulltext/pdf

DOI: 10.1002/mds.870020206

Affiliations:

Le document en format XML

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<author><name sortKey="Schechter, P J" sort="Schechter, P J" uniqKey="Schechter P" first="P. J." last="Schechter">P. J. Schechter</name>
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<term>Aged</term>
<term>Aminoacid</term>
<term>Biochemistry</term>
<term>Carnosine (analogs & derivatives)</term>
<term>Carnosine (cerebrospinal fluid)</term>
<term>Cerebrospinal fluid</term>
<term>Degenerative disease</term>
<term>Dipeptides (cerebrospinal fluid)</term>
<term>Female</term>
<term>Friedreich Ataxia (cerebrospinal fluid)</term>
<term>Friedreich ataxia</term>
<term>Friedreich's ataxia</term>
<term>GABA</term>
<term>Heredodegeneration</term>
<term>Homocarnosine</term>
<term>Human</term>
<term>Humans</term>
<term>Huntington Disease (cerebrospinal fluid)</term>
<term>Huntington disease</term>
<term>Huntington's chorea</term>
<term>Levodopa (pharmacology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (cerebrospinal fluid)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>gamma-Aminobutyric Acid (cerebrospinal fluid)</term>
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<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Carnosine</term>
<term>Dipeptides</term>
<term>gamma-Aminobutyric Acid</term>
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<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Friedreich Ataxia</term>
<term>Huntington Disease</term>
<term>Parkinson Disease</term>
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<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Biochimie</term>
<term>Chorée Huntington</term>
<term>GABA</term>
<term>Homme</term>
<term>Homocarnosine</term>
<term>Hérédodégénération</term>
<term>Hérédodégénération spinocérébelleuse Friedreich</term>
<term>Liquide céphalorachidien</term>
<term>Maladie dégénérative</term>
<term>Parkinson maladie</term>
<term>Système nerveux pathologie</term>
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<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Free and total γ‐aminobutyric acid (GABA) and homocarnosine concentrations were measured in the lumbar cerebrospinal fluid (CSF) of patients with Friedreich's ataxia, Huntington's chorea, and Parkinson's disease (with and without levodopa treatment), and compared with those determined in control subjects. Values found in Friedreich's ataxia or Parkinson's disease were not significantly different from those in controls. Unexpectedly, in Huntington patients, known to have a characteristic decrease in GABA and homocarinosine were significantly higher, whereas free GABA was not different from controls. These findings indicate that the measurement of CSF GABA and homocarnosine in patients with CNS degenerative diseases should be interpreted cautiously.</div>
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Movement Disorders (revue)

Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea

Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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